Timing of Initiation of Methylprednisolone Pulse Therapy in Patients with COVID-19

High-dose methylprednisolone pulse therapy is widely used in patients with severe COVID-19. This known to have sufficient clinical effectiveness, but the optimal administration method not known. In this study, we assessed deterioration of oxygenation after COVID-19 according disease severity (oxygen requirement) at initiation therapy. Ninety-nine who received Saitama Medical University Hospital Japan between October 2020 and 2021 were retrospectively reviewed. Clinical outcomes compared fraction inspired oxygen as a measure Based on FIO2 level therapy, classified into an early treatment group (FIO2 ≤ 0.39; n = 21), middle 0.40–0.69; 38), late ≥ 0.70; 40). The frequency mechanical ventilation days lower than other groups. adverse events was also group. Both may lead further increase events.